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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

冲击奖项:如果这届奥斯卡最佳影片的提名数有9或10部电影的话,那么《逃出绝命镇》能占一个。乔登皮尔的剧本应该一定会被提名。
Lori Steele

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

['autreid?]
Whatever the underlying cause, last year’s extreme warmth in the West meant that Alaska, Arizona, California and Nevada all set temperature records. Some parts of California essentially had no winter last year, with temperatures sometimes running 10 to 15 degrees above normal for the season. The temperature in Anchorage, Alaska’s largest city, never fell below zero in 2014, the first time that has happened in 101 years of record-keeping for the city.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

Trium在三个指标上名列第一:攻读课程前学员的工作经历、实现的目标,以及国际课程经历。该课程学员在毕业3年后的平均薪资排名第二(30.7003万美元),仅次于Kellogg/HKUST联合推出的课程。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

I'm only a child yet I know we are all in this together and should act as one single world towards one single goal. 我身为小孩都知道,我们在地球的母亲怀中都是孩子。我们应该为了相同的目的进行相同的行动!

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

While falling prices for oil and other inputs have supported profit margins, the positive impact has been outweighed by falling prices for finished goods, He Ping, a statistician at the bureau’s industrial department, said in a statement accompanying the data.
The new image will replace that of Alexander Hamilton, the nation's first Treasury Secretary, whose portrait has graced the $10 bill since the late 1920s. The redesigned currency will debut in time for the 100th anniversary of the formal ratification of the constitutional amendment that gave women the right to vote.
J.P. Morgan slides to fourth place as its total composite score slipped behind Agricultural Bank of China. Say goodbye to the two Europe-based companies in Top 10 last year, Royal Dutch Shell (No.11) and HSBC Holdings (No.14).
The US remains home to the biggest brands and the value of its top 10 increased by 10 per cent to $1.3tn in 2016. The top 10 UK brands, headed by Vodafone, lost 8 per cent of their value. Those in continental Europe — led by Germany’s SAP software group — rose 5 per cent. Finally, the $360bn value of Asia’s top 10 brands, headed by Tencent, China Mobile and Alibaba, was only 10 per cent lower than the value of the top 10 in continental Europe and the UK combined.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

Benito Mussolini and Adolf Hitler are case studies of demagogues turned into despots.
《纸牌屋》(House of Cards),Netflix,2月27日播出。Netflix的政治大戏,第三季有13集。除凯文·斯派西(Kevin Spacey)与罗宾·怀特(Robin Wright)外,曾出演《忧愁河上桥》(Treme)的基姆·迪金斯(Kim Dickens)亦加盟该剧,“Pussy Riot”的两位成员亦有客座出演。
Average years of work experience: 10 in Philadelphia, 12 in San Francisco
2016年,担忧和愤怒主导了英国和美国这两个最重要、稳定、悠久的民主政体的政治情绪。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

这项发明是伟大的,但也是愚蠢的。”这个开瓶器号称是“世界上第一个智能开瓶器”,但它不是突破性的。这个开瓶器能在你开酒瓶的时候通过短信发消息通知你的好友,这很疯狂,对吗?

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

n. 锦标赛,冠军,拥护

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

《一名拍摄黑手党的西西里摄影师和她的“鲜血档案”》(A Sicilian Photographer of the Mafia and Her ‘Archive of Blood’)
romantic

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Jennifer Lawrence is one of the hottest young actresses in Hollywood right now, so it's no surprise that a lot of men find her to be irresistible.
5. Starbucks. Brand love: 26% / Social Business Index Rank: 26

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

同时,乔金-诺阿和交易无缘,因为甚至都没有关于他的交易流言。
富达国际(Fidelity International)旗下全球地产基金的投资组合经理德克?菲利帕(Dirk Philippa)也削减了在香港的投资,把配置比重从两年前相对基准超配6%至8%调整至超配1%。

Graphical abstract: Diagnostic technologies for COVID-19: a review
From the themed collection: 家装公司进入装修停工期
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

● 一群非法投票人在六个投票点出现给希拉里投票,你们还以为选民骗局是假的吗?
Kathryn Bigelow and screenwriter Mark Boal have been working for a while on a drama about the 1967 police raid in Detroit, which led to one of the largest citizen uprisings in US history. Kaitlyn Dever, John Krasinski, Will Poulter, John Boyega and Jack Reynor star.
报告还发现,在“智力资本和创新”及“技术成熟度”等指标方面排名较高的城市综合排名也很高,这很明确地表明,技术上先进的城市更有可能成为“机遇城市”。
我可能会说:“我解雇你是因为你工作不达标。”实际上,我并不会说是因为你实在让人受不了,每次和人沟通都会得罪人。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

自动驾驶汽车:研究人员正在研究能让汽车自动倒车入库的设备,让你甚至不必坐在车里就能完成倒车。这样你就不必在不小心刮蹭到别人的车时,往人家的雨刮器下面留张字条,并附上你的电话号码了。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

圣保罗报的民意调查是基于在贝洛奥里藏特(Belo Horizonte)的米内朗球场( Mineirao)对693名球迷进行的采访,统计误差为4%左右。
boring

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
From the themed collection: “四低”态势仍将被延续
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

Summly对这一难题的解决方式是创建文章的“快照”,比起阅读整篇文章,该功能可提高读者的浏览速度。尽管应用将关闭,但达洛伊西奥的技术将整合进雅虎的移动应用。

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

vt. 妥协处理,危

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

加拿大人:到了英国,你们恐怕会一次又一次地被人误认为是美国人,还会因为那些和你们毫无关联的事情而备受指责。除非你能想出一种简便快速的办法,让人一眼就能看出你是加拿大人(在衣领上夹一朵花?穿马鞍鞋?戴枫叶图案的眼罩?)要不然你也就只能慢慢习惯,不再抱怨了。
“当我刚开始创业的时候,布鲁克林还是个替代选项;而现在,它已经成为一个优选地段了,”霍尔斯特德房地产公司(Halstead Property)的首席执行官黛安娜·M·拉米雷斯(Diane M. Ramirez)说,“我看到皇后区(Queens)正在朝这个方向发展,布朗克斯(Bronx)也不远了。”
6.摄影记者
It's a travel pillow that bends to support your head in any position.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

The 12 US schools that appear in this ranking are the most gender balanced on average, with cohorts that are 48 per cent female.
单词appearance 联想记忆:
根据美国海洋和大气管理局的数据,美国本土今年1月至11月的气温是有史以来每年前11个月的最高记录。2012年还将超过1998年,成为美国有记录以来最热的一年。
CPI涨幅放缓主要是由食品价格导致的,尽管食品价格涨幅仍高于总体涨幅。10月份,食品价格同比上涨1.9%,低于9月份的2.7%和8月份的3.7%。非食品价格涨幅从1.0%降至0.9%。
“As long as overall markets remain relatively constructive and transactions continue to be executed well, we continue to expect healthy volumes over the rest of the year,” said David Ludwig, head of Americas equity capital markets at Goldman Sachs.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

当瑞秋·布鲁姆听闻自己赢得喜剧类电视最佳女主角奖项时,喜极而泣。亚马逊节目《丛林中的莫扎特》也意外斩获最佳剧集奖项。
While Jaws's story is extremely unrealistic, it was based on a real series of deaths attributed to a single shark in 1916. In what has been dubbed the "most unique set of shark attacks that ever have occurred," the Jersey Shore saw four people die from shark bites over the course of two weeks. The offending shark was reportedly caught with body parts still in its digestive tract, although leading scientists still aren't sure what drove it to attack so many people.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

But that hasn't stopped scientists from growing actual human brains in a lab. Starting with nothing but stem cells, scientists in Austria this year managed to create brains equivalent to those in nine-week-old fetuses. These miniature brains are the size of peas and are incapable of thought—so far. The one thing keeping the brains from growing beyond this stage and becoming fully functional is that they have no blood supply.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

The report said there were now 594 dollar billionaires in China, putting China ahead of the United States' 535. However, none of China's super-rich make it into the global top 20.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
From the themed collection: 广州住房公积金租售中心上线
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

The survey of 11,500 workers by Chinese employment agency Zhaopin found that 50.9 per cent did not get an annual bonus at the end of 2016. Another 9.6 per cent were told their bonus had been delayed until after the new year holiday.
Nothing else matters, not even basic astronomy.
There are 15 Chinese brands in the top 100, one more than last year and a sharp rise on a decade ago, when China Mobile was the only Chinese brand.
公司:The Grommet公司

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
From the themed collection: 8月佛山陶瓷价格指数走势分析
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

"The Chinese government, universities and investors have provided a friendly environment for young startups. However, the failure rate of fresh graduates founding startups is still too high due to the lack of experience, resources and networking," said Wang Yixin, a senior consultant at Zhaopin.
恭贺新禧,万事如意。
But a friend saw a TV report about it and contacted the sorting office. Mr Siddeeq, 74, says he is still eager to read it, despite now being divorced。
stable

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

[.h?spi't?liti]
Experts say that 2016 was a remarkable year for the Chinese film industry as it realized growth while facing multiple challenges including the rapid development of the internet, the increasingly sophisticated tastes of Chinese audiences, and the economic downturn in the country.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

塞巴斯蒂安佩恩(Sebastian Payne)
“有个人给同事发了条短信说自己辞职了,并请她把这条短信转发给高管。”
Song “The Sacred Land” (Sun Nan)
4.The Mask Of Zorro
For the first time in six years, a new challenger has topped the FT’s ranking of executive MBA programmes.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

该排行榜为有工作经验的高级管理人员评出全球最优秀的100个EMBA项目。
首先,Bitstamp遭遇黑客袭击,以及2011年黑客袭击比特币交易平台Mt. Gox(此次黑客袭击要严重得多,其损失当时约合4亿美元),往往被误解为比特币本身存在安全问题。但事实上,这只能表明上述比特币交易平台存在缺陷,而非比特币技术本身存在问题。而最令人激动的,正是比特币背后的底层技术。正如《财富》杂志2015年1月刊《打造未来》系列报道中所写,大部分极为看好比特币、为其大声疾呼的狂热粉丝(包括马克o安德森这样的大牌企业家,也包括花大把时间更新比特币REDDIT页面的开发者和比特币“矿工”),更感兴趣的是能建立在比特币“区块”(该货币基本骨架)上的应用,而非比特币货币体系。两个实体间可通过“区块”安全交换任何形式的价值。
They will get more creative in 2018, including on non-cash benefits. Bank of America, for example, has just introduced a programme allowing employees of the global banking and markets unit to take a sabbatical — on full pay — for up to six weeks in a year. There are conditions: people must have been with the bank for at least a decade, and can request the time once every five years, to a maximum of three. But in a memo circulated this week, seen by the Financial Times, chief operating officer Tom Montag urged eligible employees to consider it.

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

潘通在解释这一选择时提到以下这些因素:“主张性别平等和流动性的社会运动;消费者越来越喜欢把色彩当作一种表达方式;这一代人不太在意被认定为某一种类型或遭到评判;公开的数字信息交流让我们看到颜色使用的不同方式。”
Summly attempts to solve this problem by creating “snapshots” of stories that allow readers to browse more quickly than reading full articles. The app will close down but Mr D’Aloisio’s technology will be integrated into Yahoo’s mobile apps.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
From the themed collection: 供需活跃 50城土地储备连涨12个月
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

周期性理论的依据是,新投资不足将导致两三年或五年后出现供应紧张。大量的项目已被延迟,但这对于项目经理而言,不过是要想办法削减成本的一种信号。许多项目经理目前就在这么做。
Disparity between the 34 cities surveyed was still greater, as the the average bonus of over Rmb15,800 in Beijing was more than triple the lowest-paying city of Shenyang, the provincial capital Liaoning located in China’s northeastern rust belt.
n. [计]定序;排序;订购 v. 命令;指挥;订购(o

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
From the themed collection: 振兴东北关键要破解人才流失问题
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

一位伦敦软件神童的“硅谷梦”成真,雅虎(Yahoo)斥资近3000万美元收购了他制作的新闻应用。
4.《欲望都市》掀起纸杯蛋糕热
这款高端机型将成为苹果产品阵容的一名新成员,加入去年发布的、升级步伐较小的iPhone 7和iPhone 7 Plus的行列。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

Dachis says: The end of year iPhone 5 and iPad Mini releases overcame early controversies in overseas manufacturing and any lingering effects from the death of Steve Jobs to make Apple the biggest mover of the year.

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

加工食品、汽水和快餐商家将发展中国家市场视为他们最重要的发展机遇。与此同时,发展中国家的肥胖率以及与体重相关的疾病也在上升。一系列文章以巴西、加纳和哥伦比亚为例,研究了这两种趋势之间的相互作用。总的来说,这些故事揭示了“新的全球食品秩序和健康危机”。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

Lisa Stone
沃尔玛百货

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

凯投宏观(Capital Economics)中国经济学家朱利安?埃文斯-普里查德(Julian Evans-Pritchard)评论道:“结果是,上个月中国的贸易看起来惊人强劲。在全球需求强劲的背景下,我们预期未来数月出口还将继续表现良好。”
节目19 歌曲《一辈子朋友》,杨坤 张靓颖
I'm going to disagree on one team you mentioned: the Kings. The West is a bit shallow again, and Sacramento is in the mix for a playoff spot. It's not likely or anything, but so long as they are in the mix, they have to pull out almost all the stops to grab it.
The most striking thing about the UK’s looming exit from the EU is how few details we still know about what Brexit will bring. And that it has been more than a year since the referendum.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

如果说2017年是政策制定者们开始担心“无保障无产阶级”(precariat)人数增长的一年,那么2018年将是他们尝试为此做些什么的一年。
X

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

['w?:θ'wail]
?Bond is by no means a comedian but he knows the power of a well-timed one liner. Women are attracted to funny men because humor is a sign of intelligence. You can even predict how many women a man has slept with by how funny he is.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 京津冀投洽会发布367个项目
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

7. 阿里尔·福克斯曼《型时代》

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

China has all long and continues to support a united, prosperous and stable European Union, support a strong Euro, and support European integration process. We believe that is good for globalization, for a multipolar world and for diversity of civilizations. We feel optimistic about the future of the EU and the future of China-EU relations.
201107/145539.shtml
……一边说从来不会让人看到他流汗,一边汗流不止。
With Westbrook playing such a hands-on, high-usage role and Victor Oladipo already locked in on a high-dollar extension, Payne needed to prove he could be an off-ball threat or a lead guard on the second unit.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

在这月初这封信上写着的地址是宾夕法尼亚大学的某个邮箱。
200911/88512.shtmlDuring NATO’s 1999 air war over Yugoslavia the Atlantic alliance struck hundreds of targets over Serbia and Kosovo. Most were uncontroversial: air-defense sites army headquarters and other military targets. The destruction of one target in particular however set off a wave of anti-Western—and anti-American in particular—protests half a world away. That target was the Chinese embassy in Belgrade.

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

入围名单以聚焦科技业的图书为主,Basic Books和Oneworld Publications出版的《机器人的崛起:大规模失业的威胁与科技》最终战胜了强大的对手。
Developer: Supermassive Games, Sony Computer Entertainment
? President Obama declared a "major disaster" in New York and New Jersey. Flooding devastated the coast and more than 2.3 million lost power. The National Guard rescued hundreds from flooding in New Jersey. The governor, Chris Christie, a Republican, said the damage was "unthinkable". He praised the "outstanding" co-operation he had received from Obama.

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

The approach has in some cases moved from the political fringes into the mainstream. Some leaders from Britain’s center-right, governing Conservative Party, for example, helped push a British exit, and since the referendum the new Conservative prime minister, Theresa May, has signaled sympathy with white identity politics.
Management and leadership skills are just one aspect of EMBAs. “It actually made an entrepreneur of me,” says one graduate. Nearly a third (31 per cent)of graduates have set up their own company, or are about to, since enrolling on their EMBA four or five years ago. FT data show that 91 per cent of the businesses are operating today.
Media reports from both countries, which have been involved in rising tensions over territories in the South China Sea, lay the blame on the their respective governments for illegal foods entering their markets.

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

comedy
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Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
From the themed collection: 武汉首创应届生申请大学生租赁房
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
From the themed collection: 百强房企市场集中度继续提升
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

[.s?:kju'lein]
年龄:31岁
根据普京最近的一次收入申报,2015年他总计收入大约为890万卢布(约合13.7万美元)。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

QK%.jd&KnAkQ
【编辑语】应聘时必须面对HR,工作期间可能需要HR,离职时还是离不开HR。HR是公司中最深谙职场秘密的部门。以下的18条评论是来自于美国各知名公司的HR或是专业人力资源机构的讲师,其中包括知名作家,前人力资源经理Cynthia Shapiro(《企业机密:50条公司不会告诉你的秘密》一书的作者)。我们一起来了解下吧。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

Faster progress in work to improve environment, particularly air quality, is what people are desperately hoping for, and is critical to sustainable development. We must adopt well-designed policies, tackle both symptoms and root causes, and take tough steps to make the grade in responding to the people.
2017年度国家公务员考试上周日开考,大学生自主创业和"玉兔"月球车等最近的热门话题进入国考考题。
China is now home to over 80,000 trade markets and total retail sales of consumer goods would reach 30 trillion yuan this year with consumption contributing to about 60 percent of total GDP growth, Gao said.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

被调查的34个城市间的差距就更大了。北京市平均年终奖超过1.58万元人民币,超过了年终奖最低的沈阳市的三倍。沈阳市是中国东北铁锈地带辽宁省的省会。

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

It’s been one of the worst years for investment decision-making on record, almost across the board. No strategy worked consistently, save for the type of shareholder activism that only a handful of Wall Street’s billionaire titans are able to engage in.
Yes. There are plenty of positives: earnings, economic growth, and US tax cuts. But they are already known. Stocks look ridiculously expensive by historical standards, but that tells us nothing about short-term moves. Ultimately, it comes down to liquidity, which has driven markets since they emerged from the crisis in 2009. If all goes according to plan, central banks will be decreasing their balance sheets, and removing liquidity, by the end of 2018. If they go through with this, the odds are that the S&P will stall. But even a tiny tremor could make the bankers blink. Expect the momentum to continue.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

这个家庭中心内部有三个摄像头,它能够连接到你的手机,你可以通过手机看冰箱里有什么。所以它基本上是一个6000美元替代用纸笔完成购物清单的替代品。
This year, pop's best albums came from strong women who had a lot to say: Lorde's searing look at loneliness, Kesha's raucous statement of liberation, Taylor Swift's reckoning between her self and the version presented in the press.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

There will not likely be a return to the whiteness of social dominance and exclusive national identity. Immigration cannot be halted without damaging Western nations’ economies; immigrants who have already arrived cannot be expelled en masse without causing social and moral damage. And the other groups who seem to be “cutting in line” are in fact getting a chance at progress that was long denied them.
尽管该片被洛杉矶影评人协会评为最佳剪辑奖,但却没有受到纽约影评人的重视。它的势头会逐渐减弱吗?

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

他表示:“消费者将需要更多时间回归,这就是为什么我们聚焦于一项我们知道会奏效的方案,专注于价格可承受能力和城市地区的高端(饮料)。”他补充称,他相信,该公司将继续在中国扩大市场份额,同时正为消费者支出再次提速做好准备。
The system for ensuring responsibility is taken for poverty elimination will be effectively enforced, the strictest possible evaluations and assessments of poverty alleviation will be carried out, and stern measures will be taken to address deception, falsification, and the manipulation of numbers in poverty elimination work. We must see that the results of our poverty elimination earn the approval of our people and stand the test of time.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

以下四个因素应该会对2013年的就业复苏起到推动作用:[qh]

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

科学圈外的人士对论文撤稿的反应不一。
No. The much-hyped US electric carmaker once promised to make 400,000 of its new dream machines in 2018. Its latest production targets imply 200,000-300,000. But serious glitches in battery production have meant a slow start, and Tesla’s record is not good. With Tesla yet to show it can wean itself off constant infusions of Wall Street cash, 2018 cold be a make or break year.
但国家统计局认为,CPI上涨的主要原因是去年同期对比基数相对偏低。
1.Rain Man

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

电商巨头阿里巴巴集团创始人、董事局主席马云连续第三年成为我国"IT首富"。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: 前四月我国建材商品出口增长22%
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

以下是专家提供的,明年的生存和发展建议:
14. On the Other Hand Here is an estimate of the movies directed by women that were released by major studios this year: Warner Bros. (five! — Lana Wachowski, Anne Fletcher, Dana Nachman, Nancy Meyers, Patricia Riggen); Universal (three — Sam Taylor Johnson, Elizabeth Banks, Angelina Jolie); Disney (one — Niki Caro); Paramount (0); Fox (0); and Sony (0). (I excluded Fox and Sony’s specialty units.)
但是政客们究竟会做什么呢?虽然特朗普总统致力于让传统制造业岗位回流美国,但美国好几个州正在试验其他政策来帮助无保障的低收入工人。这些政策各有不同,既有大幅提高最低工资标准的措施,也有阻止雇主在最后一刻调整员工时间表的新规。

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Though Hand was British Petroleum's SVP of Global Brand, Marketing and Innovation, for several years, she's on a much more environmentally friendly mission today. Project Frog aims to revamp the construction industry with simple-to-build spaces (they takes days, rather than months to construct) that consume about 50% less energy than traditional buildings for sectors like education and healthcare. Hand's plan seems to be working: revenue is expected to more than double this year.
People on both sides of the Taiwan Strait are brothers and sisters, and no matter how the situation on the island evolves, the mainland is determined to maintain Cross-Strait stability.

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

9.澳大利亚贝拉林半岛
Obama watched the returns on television at his Chicago home. Senior campaign strategist David Axelrod said via email that he was feeling "great."

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

1)谢谢:只是一般的礼貌?没错。那你告诉我,上一次你忘了说(或者拒绝说)谢谢是在什么时候?无论是在公开场合还是在私底下,说一句真诚的“谢谢”都会为你树立好口碑。也别忘了妈妈给你的忠告,“说请”。人们都喜欢比人请自己去做事而不是接受别人的命令去干活。

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
From the themed collection: 阎焱辞任雷士照明董事长
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

不过,我们大部分人都有自知之明,在粉饰过去的同时就已意识到自己是在自欺欺人。我们知道这种倾向在政治界的危害(看看布什和克林顿吧)。可是,在时尚界又何尝不是如此呢?
championship
Believe it or not, this prize went to the US Government General Accountability Office (GAO) for issuing a report that recommended a report about another report of reports recommending reports... or something like that.

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

Rafael Corrales, a partner at Charles River Ventures, believes that the growth in a wide range of fields—from academia to infrastructure to policy—is a sign that 2014 was the biggest year bitcoin has had yet, despite its volatility. “In the short-term, that’s an easy knock from people who don’t understand or believe it can be something,” he says. “It’s the easiest thing for them to go after. In that transition stage, you’re going to have extreme volatility, so looking at its value over one year is kind of silly.” As for occasional hacks, he adds, “There are going to be bumps in the short term, but they’ll be solved sooner than later. And these things are being addressed by a huge community of people. So you have to be really excited, despite small bumps.”
另外一件性玩具则显然属于中国皇室。
Celebritites always seem to have a better life than the rest of us;nicer house,cooler cars and even cuter children.Just look at these pictures of Shiloh Jolie-
《死侍》将于2016年2月12日爆笑上映。 当然,电影中还有不少动作和杀戮场景。

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

人事工作类
The King’s Woman

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

Mr Hoogewerf said that Mr Wang delisted his group’s property arm from the Hong Kong stock exchange this year in the hope of realising a richer valuation for it on the Shanghai or Shenzhen bourse.
[k?n'gr?tju.leit]
不过邱佩特并不只是一只宠物猫,它只参与了两个广告的拍摄就在一年里独自挣得了230多万英镑,其中一个是为日本美容产品植村秀拍摄的,另一个则是为德国汽车公司沃克斯豪尔拍摄的。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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But not every reporter (including this one) would agree with the final assessment.
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