Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Whatever the underlying cause, last year’s extreme warmth in the West meant that Alaska, Arizona, California and Nevada all set temperature records. Some parts of California essentially had no winter last year, with temperatures sometimes running 10 to 15 degrees above normal for the season. The temperature in Anchorage, Alaska’s largest city, never fell below zero in 2014, the first time that has happened in 101 years of record-keeping for the city.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
I'm only a child yet I know we are all in this together and should act as one single world towards one single goal. 我身为小孩都知道，我们在地球的母亲怀中都是孩子。我们应该为了相同的目的进行相同的行动！
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
While falling prices for oil and other inputs have supported profit margins, the positive impact has been outweighed by falling prices for finished goods, He Ping, a statistician at the bureau’s industrial department, said in a statement accompanying the data.
The new image will replace that of Alexander Hamilton, the nation's first Treasury Secretary, whose portrait has graced the $10 bill since the late 1920s. The redesigned currency will debut in time for the 100th anniversary of the formal ratification of the constitutional amendment that gave women the right to vote.
J.P. Morgan slides to fourth place as its total composite score slipped behind Agricultural Bank of China. Say goodbye to the two Europe-based companies in Top 10 last year, Royal Dutch Shell (No.11) and HSBC Holdings (No.14).
The US remains home to the biggest brands and the value of its top 10 increased by 10 per cent to $1.3tn in 2016. The top 10 UK brands, headed by Vodafone, lost 8 per cent of their value. Those in continental Europe — led by Germany’s SAP software group — rose 5 per cent. Finally, the $360bn value of Asia’s top 10 brands, headed by Tencent, China Mobile and Alibaba, was only 10 per cent lower than the value of the top 10 in continental Europe and the UK combined.
Trends and targets in antiviral phototherapy
Benito Mussolini and Adolf Hitler are case studies of demagogues turned into despots.
《纸牌屋》(House of Cards)，Netflix，2月27日播出。Netflix的政治大戏，第三季有13集。除凯文·斯派西(Kevin Spacey)与罗宾·怀特(Robin Wright)外，曾出演《忧愁河上桥》(Treme)的基姆·迪金斯(Kim Dickens)亦加盟该剧，“Pussy Riot”的两位成员亦有客座出演。
Average years of work experience: 10 in Philadelphia, 12 in San Francisco
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
《一名拍摄黑手党的西西里摄影师和她的“鲜血档案”》(A Sicilian Photographer of the Mafia and Her ‘Archive of Blood’)
ACE2 as a potential therapeutic target for pandemic COVID-19
Jennifer Lawrence is one of the hottest young actresses in Hollywood right now, so it's no surprise that a lot of men find her to be irresistible.
5. Starbucks. Brand love: 26% / Social Business Index Rank: 26
Diagnostic technologies for COVID-19: a review
富达国际(Fidelity International)旗下全球地产基金的投资组合经理德克?菲利帕(Dirk Philippa)也削减了在香港的投资，把配置比重从两年前相对基准超配6%至8%调整至超配1%。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Kathryn Bigelow and screenwriter Mark Boal have been working for a while on a drama about the 1967 police raid in Detroit, which led to one of the largest citizen uprisings in US history. Kaitlyn Dever, John Krasinski, Will Poulter, John Boyega and Jack Reynor star.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
圣保罗报的民意调查是基于在贝洛奥里藏特（Belo Horizonte）的米内朗球场（ Mineirao）对693名球迷进行的采访，统计误差为4%左右。
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
“当我刚开始创业的时候，布鲁克林还是个替代选项；而现在，它已经成为一个优选地段了，”霍尔斯特德房地产公司(Halstead Property)的首席执行官黛安娜·M·拉米雷斯(Diane M. Ramirez)说，“我看到皇后区(Queens)正在朝这个方向发展,布朗克斯(Bronx)也不远了。”
It's a travel pillow that bends to support your head in any position.
Influenza neuraminidase: A druggable target for natural products
The 12 US schools that appear in this ranking are the most gender balanced on average, with cohorts that are 48 per cent female.
“As long as overall markets remain relatively constructive and transactions continue to be executed well, we continue to expect healthy volumes over the rest of the year,” said David Ludwig, head of Americas equity capital markets at Goldman Sachs.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
While Jaws's story is extremely unrealistic, it was based on a real series of deaths attributed to a single shark in 1916. In what has been dubbed the "most unique set of shark attacks that ever have occurred," the Jersey Shore saw four people die from shark bites over the course of two weeks. The offending shark was reportedly caught with body parts still in its digestive tract, although leading scientists still aren't sure what drove it to attack so many people.
The role of biosensors in the detection of emerging infectious diseases
But that hasn't stopped scientists from growing actual human brains in a lab. Starting with nothing but stem cells, scientists in Austria this year managed to create brains equivalent to those in nine-week-old fetuses. These miniature brains are the size of peas and are incapable of thought—so far. The one thing keeping the brains from growing beyond this stage and becoming fully functional is that they have no blood supply.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
The report said there were now 594 dollar billionaires in China, putting China ahead of the United States' 535. However, none of China's super-rich make it into the global top 20.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The survey of 11,500 workers by Chinese employment agency Zhaopin found that 50.9 per cent did not get an annual bonus at the end of 2016. Another 9.6 per cent were told their bonus had been delayed until after the new year holiday.
Nothing else matters, not even basic astronomy.
There are 15 Chinese brands in the top 100, one more than last year and a sharp rise on a decade ago, when China Mobile was the only Chinese brand.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
"The Chinese government, universities and investors have provided a friendly environment for young startups. However, the failure rate of fresh graduates founding startups is still too high due to the lack of experience, resources and networking," said Wang Yixin, a senior consultant at Zhaopin.
But a friend saw a TV report about it and contacted the sorting office. Mr Siddeeq, 74, says he is still eager to read it, despite now being divorced。
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Experts say that 2016 was a remarkable year for the Chinese film industry as it realized growth while facing multiple challenges including the rapid development of the internet, the increasingly sophisticated tastes of Chinese audiences, and the economic downturn in the country.
Inhibition of SARS coronavirus helicase by bismuth complexes
Song “The Sacred Land” (Sun Nan)
4．The Mask Of Zorro
For the first time in six years, a new challenger has topped the FT’s ranking of executive MBA programmes.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
They will get more creative in 2018, including on non-cash benefits. Bank of America, for example, has just introduced a programme allowing employees of the global banking and markets unit to take a sabbatical — on full pay — for up to six weeks in a year. There are conditions: people must have been with the bank for at least a decade, and can request the time once every five years, to a maximum of three. But in a memo circulated this week, seen by the Financial Times, chief operating officer Tom Montag urged eligible employees to consider it.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Summly attempts to solve this problem by creating “snapshots” of stories that allow readers to browse more quickly than reading full articles. The app will close down but Mr D’Aloisio’s technology will be integrated into Yahoo’s mobile apps.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Disparity between the 34 cities surveyed was still greater, as the the average bonus of over Rmb15,800 in Beijing was more than triple the lowest-paying city of Shenyang, the provincial capital Liaoning located in China’s northeastern rust belt.
n. [计]定序；排序；订购 v. 命令；指挥；订购（o
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
这款高端机型将成为苹果产品阵容的一名新成员，加入去年发布的、升级步伐较小的iPhone 7和iPhone 7 Plus的行列。
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Dachis says: The end of year iPhone 5 and iPad Mini releases overcame early controversies in overseas manufacturing and any lingering effects from the death of Steve Jobs to make Apple the biggest mover of the year.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
凯投宏观(Capital Economics)中国经济学家朱利安?埃文斯-普里查德(Julian Evans-Pritchard)评论道：“结果是，上个月中国的贸易看起来惊人强劲。在全球需求强劲的背景下，我们预期未来数月出口还将继续表现良好。”
节目19 歌曲《一辈子朋友》，杨坤 张靓颖
I'm going to disagree on one team you mentioned: the Kings. The West is a bit shallow again, and Sacramento is in the mix for a playoff spot. It's not likely or anything, but so long as they are in the mix, they have to pull out almost all the stops to grab it.
The most striking thing about the UK’s looming exit from the EU is how few details we still know about what Brexit will bring. And that it has been more than a year since the referendum.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
?Bond is by no means a comedian but he knows the power of a well-timed one liner. Women are attracted to funny men because humor is a sign of intelligence. You can even predict how many women a man has slept with by how funny he is.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
China has all long and continues to support a united, prosperous and stable European Union, support a strong Euro, and support European integration process. We believe that is good for globalization, for a multipolar world and for diversity of civilizations. We feel optimistic about the future of the EU and the future of China-EU relations.
With Westbrook playing such a hands-on, high-usage role and Victor Oladipo already locked in on a high-dollar extension, Payne needed to prove he could be an off-ball threat or a lead guard on the second unit.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
200911/88512.shtmlDuring NATO’s 1999 air war over Yugoslavia the Atlantic alliance struck hundreds of targets over Serbia and Kosovo. Most were uncontroversial: air-defense sites army headquarters and other military targets. The destruction of one target in particular however set off a wave of anti-Western—and anti-American in particular—protests half a world away. That target was the Chinese embassy in Belgrade.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
入围名单以聚焦科技业的图书为主，Basic Books和Oneworld Publications出版的《机器人的崛起：大规模失业的威胁与科技》最终战胜了强大的对手。
Developer: Supermassive Games, Sony Computer Entertainment
? President Obama declared a "major disaster" in New York and New Jersey. Flooding devastated the coast and more than 2.3 million lost power. The National Guard rescued hundreds from flooding in New Jersey. The governor, Chris Christie, a Republican, said the damage was "unthinkable". He praised the "outstanding" co-operation he had received from Obama.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
The approach has in some cases moved from the political fringes into the mainstream. Some leaders from Britain’s center-right, governing Conservative Party, for example, helped push a British exit, and since the referendum the new Conservative prime minister, Theresa May, has signaled sympathy with white identity politics.
Management and leadership skills are just one aspect of EMBAs. “It actually made an entrepreneur of me,” says one graduate. Nearly a third (31 per cent)of graduates have set up their own company, or are about to, since enrolling on their EMBA four or five years ago. FT data show that 91 per cent of the businesses are operating today.
Media reports from both countries, which have been involved in rising tensions over territories in the South China Sea, lay the blame on the their respective governments for illegal foods entering their markets.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
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Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Faster progress in work to improve environment, particularly air quality, is what people are desperately hoping for, and is critical to sustainable development. We must adopt well-designed policies, tackle both symptoms and root causes, and take tough steps to make the grade in responding to the people.
China is now home to over 80,000 trade markets and total retail sales of consumer goods would reach 30 trillion yuan this year with consumption contributing to about 60 percent of total GDP growth, Gao said.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
It’s been one of the worst years for investment decision-making on record, almost across the board. No strategy worked consistently, save for the type of shareholder activism that only a handful of Wall Street’s billionaire titans are able to engage in.
Yes. There are plenty of positives: earnings, economic growth, and US tax cuts. But they are already known. Stocks look ridiculously expensive by historical standards, but that tells us nothing about short-term moves. Ultimately, it comes down to liquidity, which has driven markets since they emerged from the crisis in 2009. If all goes according to plan, central banks will be decreasing their balance sheets, and removing liquidity, by the end of 2018. If they go through with this, the odds are that the S&P will stall. But even a tiny tremor could make the bankers blink. Expect the momentum to continue.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
This year, pop's best albums came from strong women who had a lot to say: Lorde's searing look at loneliness, Kesha's raucous statement of liberation, Taylor Swift's reckoning between her self and the version presented in the press.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
There will not likely be a return to the whiteness of social dominance and exclusive national identity. Immigration cannot be halted without damaging Western nations’ economies; immigrants who have already arrived cannot be expelled en masse without causing social and moral damage. And the other groups who seem to be “cutting in line” are in fact getting a chance at progress that was long denied them.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
The system for ensuring responsibility is taken for poverty elimination will be effectively enforced, the strictest possible evaluations and assessments of poverty alleviation will be carried out, and stern measures will be taken to address deception, falsification, and the manipulation of numbers in poverty elimination work. We must see that the results of our poverty elimination earn the approval of our people and stand the test of time.
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
No. The much-hyped US electric carmaker once promised to make 400,000 of its new dream machines in 2018. Its latest production targets imply 200,000-300,000. But serious glitches in battery production have meant a slow start, and Tesla’s record is not good. With Tesla yet to show it can wean itself off constant infusions of Wall Street cash, 2018 cold be a make or break year.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
14. On the Other Hand Here is an estimate of the movies directed by women that were released by major studios this year: Warner Bros. (five! — Lana Wachowski, Anne Fletcher, Dana Nachman, Nancy Meyers, Patricia Riggen); Universal (three — Sam Taylor Johnson, Elizabeth Banks, Angelina Jolie); Disney (one — Niki Caro); Paramount (0); Fox (0); and Sony (0). (I excluded Fox and Sony’s specialty units.)
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Though Hand was British Petroleum's SVP of Global Brand, Marketing and Innovation, for several years, she's on a much more environmentally friendly mission today. Project Frog aims to revamp the construction industry with simple-to-build spaces (they takes days, rather than months to construct) that consume about 50% less energy than traditional buildings for sectors like education and healthcare. Hand's plan seems to be working: revenue is expected to more than double this year.
People on both sides of the Taiwan Strait are brothers and sisters, and no matter how the situation on the island evolves, the mainland is determined to maintain Cross-Strait stability.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Obama watched the returns on television at his Chicago home. Senior campaign strategist David Axelrod said via email that he was feeling "great."
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Believe it or not, this prize went to the US Government General Accountability Office (GAO) for issuing a report that recommended a report about another report of reports recommending reports... or something like that.
Length-scale dependence of protein hydration-shell density
Rafael Corrales, a partner at Charles River Ventures, believes that the growth in a wide range of fields—from academia to infrastructure to policy—is a sign that 2014 was the biggest year bitcoin has had yet, despite its volatility. “In the short-term, that’s an easy knock from people who don’t understand or believe it can be something,” he says. “It’s the easiest thing for them to go after. In that transition stage, you’re going to have extreme volatility, so looking at its value over one year is kind of silly.” As for occasional hacks, he adds, “There are going to be bumps in the short term, but they’ll be solved sooner than later. And these things are being addressed by a huge community of people. So you have to be really excited, despite small bumps.”
Celebritites always seem to have a better life than the rest of us;nicer house,cooler cars and even cuter children.Just look at these pictures of Shiloh Jolie-
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
The King’s Woman
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Mr Hoogewerf said that Mr Wang delisted his group’s property arm from the Hong Kong stock exchange this year in the hope of realising a richer valuation for it on the Shanghai or Shenzhen bourse.
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But not every reporter (including this one) would agree with the final assessment.